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Citation 2. Link to... LIBRARY HOLDINGS
Unique Identifier
12106640
Medline Identifier
22101853
Record Owner
NLM
Authors
Ouyang P.
Institution
Division of Cardiology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA. pouyang@jhmi.edu
Title
Methods for evaluating the effects of new hormone replacementtherapy compounds on coronary artery disease. [Review] [32 refs]
Source
American Journal of Cardiology. 90(1A):44F-50F, 2002 Jul 3.
Abbreviated Source
Am J Cardiol, AM. J. CARDIOL.. 90(1A):44F-50F, 2002 Jul 3.
NLM Journal Code
0207277, 3dq
Journal Subset
AIM, IM
Local Messages
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Country of Publication
United States
MeSH Subject Headings
Brachial Artery / ph [Physiology] Coronary Arteriosclerosis / pp [Physiopathology] *Coronary Arteriosclerosis / pc [Prevention & Control] Coronary Arteriosclerosis / ra [Radiography] Coronary Arteriosclerosis / us [Ultrasonography] Coronary Vessels / ph [Physiology] Coronary Vessels / us [Ultrasonography] Drug Evaluation *Estrogen Replacement Therapy Estrogens / pd [Pharmacology] Female Human Methylation Receptors, Estrogen / de [Drug Effects] Regional Blood Flow Sensitivity and Specificity Severity of Illness Index Tomography, X-Ray Computed / st [Standards] Ultrasonography, Interventional / st [Standards]
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Abstract
The clinical effect of hormone replacementtherapy (HRT) on cardiovascular disease, and whether this effect is altered by the formulation of estrogen or progestin studied, is an area of controversy. Use of clinical end points for these studies requires large numbers of subjects observed for several years and is time consuming and costly. The selection of clinically relevant surrogate endpoints, however, is complex, because many of the currently available modalities are not sensitive enough to identify subclinical coronary disease or disease progression. Moreover, many of the existing choices are invasive and may not be appropriate for repeated assessment of disease. This article reviews some of the available diagnostic tools, including measures of arterial structure and function, intravascular ultrasound, and electron-beam computed tomography, and assesses their ability to evaluate the presence and severity of atherosclerosis and the impact of HRT on coronary artery disease progression. [References: 32]
CAS Registry/EC Number
0 (Estrogens). 0 (Receptors, Estrogen).
ISSN
0002-9149
Publication Type
Journal Article. Review. Review, Tutorial.
Language
English
Entry Date
20020731
Update Date
20020801
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