THERAPY SEARCH TECHNIQUES

THERAPY SEARCH EXAMPLE

This strategy will filter the articles on using anticoagulants in patients with atrial fibrillation, retrieved in search statement 3, to those articles that contain evidence-based information essential to deciding whether or not to prescribe an anticoagulant for a patient with atrial fibrillation.

# Search History Results Comments
1 exp *anticoagulants/tu 1734 Notice the use of the /tu (therapeutic use) subheading
2 exp atrial fibrillation/dt 644 Notice the use of the /dt (drug therapy) subheading
3 1 and 2 123
4 (clinical or control$ or compar$) adj (trial$ or study or studies).ti,ab,sh. 44025
5 3 and 4 16 When we combine the results of sets #3 and #4, we find 16 articles that include keywords indicating that trials/studies are reported.
6 (multicenter$ or multicentre$ or multi-centre$ or multi-center$).ti,ab,sh. 8800
7 3 and 6 6 When we combine the results of sets #3 and #6, we find 6 articles that include keywords indicating that multicenter studies are reported.
8 (blind$ or mask$ or placebo$).ti,ab,sh. 30124
9 3 and 8 7 When we combine the results of sets #3 and #8, we find 7 articles that include keywords indicating that double-blind method, or placebos are reported.

Instead of using keywords, you can also try using the "Placebos" and "Double-blind method" subject headings.

10 5 or 7 or 9 23 Combining #5 or #7 or #9 simply groups the results of our three searches into one set containing a total of 23 articles.

As you can see, there is no single perfect way to apply therapy search techniques. Try various combinations of subject headings, subheadings, and keywords, in a step-by-step building process.

Let's move on to DIAGNOSIS questions.